کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5674065 | 1593683 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Reversal of resistance in bacteria underlies synergistic effect of essential oils with conventional antibiotics
ترجمه فارسی عنوان
واکنش مقاومت در باکتریها اثر سینرژیستی اسانس ها را با آنتی بیوتیک های معمولی تحت تاثیر قرار می دهد
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کلمات کلیدی
CFUCLSIESBLRPMIMBCMHAMICMMCDMEMMDRGC/MS - GC / MSMTT - MTTAntibiotics - آنتی بیوتیک هاAntibiotic - آنتی بیوتیکهاMRSA - استافیلوکوک اورئوس مقاوم به متی سیلین یا MRSA methicillin-resistant Staphylococcus aureus - استافیلوکوک اورئوس مقاوم به متیسیلینMulti-drug-resistant bacteria - باکتری مقاوم در برابر چند داروminimum bactericidal concentration - حداقل غلظت باکتریMinimum inhibitory concentration - حداقل غلظت مهاریEssential oil - عطرمایه یا اسانسMultidrug resistant - مقاوم در برابر چند داروRoswell Park Memorial Institute medium - موسسه خاطرات Roswell Park mediumSynergism - همکاریcolony-forming unit - واحد تشکیل کلنی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروب شناسی
چکیده انگلیسی
The pervasive of bacterial resistance earnestly threaten the prevention and the treatment of infectious diseases. Therefore, scientific communities take precedence over development of new antimicrobial agents. The aim of the study was to determine antimicrobial potency of three North-African essential oils Pituranthos chloranthus, Teucruim ramosissimum and Pistacia lentiscus individually, and in combination with antibiotics, to inhibit the growth of highly resistant clinical pathogen. Bacteria clinically isolated from patients, subsequently, challenged to a panel of drugs to determine the antibiotic-resistance profiles. Drugs displaying clinically irrelevant CMI were subjected to further studies in order to rescue antibiotic actions. Singular activity of essential oils and activity when combined with an antibiotic was hence elucidated. The results obtained highlighted the occurrence of strong antibacterial potential of essential oils when administrated alone. In the interactive experiment essential oils were found highly effective in reducing the resistance of Methicillin-resistant Staphylococcus aureus to amoxicillin, tetracycline, piperacillin, ofloxacin and oxacillin and resistance of Acinetobacter baumannii to amoxicillin and to ofloxacin in interactive manner. Furthermore, the results proved synergism among essential oils and both antibiotics ofloxacin and novobiocin against the Extended-Spectrum Beta-Lactamase producing E. coli (ESBL). Time kill kinetics was performed with a combination of sub-inhibitory concentrations to confirm the efficiency and killing rate of the combination over time. Further, the hypothetical toxicity of essential oils against human keratinocytes HaCat and murine spleenocytes were examined. The chemical composition of essential oils was assessed by GC/MS analysis and the major constituents found were sabinene, limonene, terpinen-4-ol, and β-eudesmol.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbial Pathogenesis - Volume 106, May 2017, Pages 50-59
Journal: Microbial Pathogenesis - Volume 106, May 2017, Pages 50-59
نویسندگان
Aida Lahmar, Ahmed Bedoui, Imen Mokdad-Bzeouich, Zaineb Dhaouifi, Zahar Kalboussi, Imed Cheraif, Kamel Ghedira, Leila Chekir-Ghedira,