کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5674716 1408254 2017 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Role of Chromatin Structure in Gene Regulation of the Human Malaria Parasite
ترجمه فارسی عنوان
نقش ساختار کروماتین در تنظیم ژن انگل مالاریا انسانی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
چکیده انگلیسی
The human malaria parasite, Plasmodium falciparum, depends on a coordinated regulation of gene expression for development and propagation within the human host. Recent developments suggest that gene regulation in the parasite is largely controlled by epigenetic mechanisms. Here, we discuss recent advancements contributing to our understanding of the mechanisms controlling gene regulation in the parasite, including nucleosome landscape, histone modifications, and nuclear architecture. In addition, various processes involved in regulation of parasite-specific genes and gene families are examined. Finally, we address the use of epigenetic processes as targets for novel antimalarial therapies. Collectively, these topics highlight the unique biology of P. falciparum, and contribute to our understanding of mechanisms regulating gene expression in this deadly parasite.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Trends in Parasitology - Volume 33, Issue 5, May 2017, Pages 364-377
نویسندگان
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