کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5697493 | 1410310 | 2016 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pour comprendre : l'activation lymphocytaire T
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
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چکیده انگلیسی
T cells activation is a finely regulated process to establish an effective anti-infectious or antitumor immune response while avoiding harmful autoimmune reactions. Although T cells are considered to be the main protagonists of the antitumor immune response, they act in interaction with other immune cells. The meeting of naive T cells with dendritic cells induces their differentiation into effector cells following the recognition of the peptide-MHC complex by the T cell receptor. The interaction of costimulatory molecules present on the surface of T cells with their ligand (s) expressed by mature dendritic cells contribute to the optimal T cell activation and to the formation of the immunological synapse. Conversely, engagement of inhibitory receptors expressed by T cells induces a negative feedback involved in the T cells homeostasis but also in the tumor escape from the immune system. The integration of stimulatory signals contributes to the proliferation, the survival and the differentiation of T cells whereas the inhibitory signals permit their regulation. The better understanding of T cell activation mechanisms has led to the development of therapeutic strategies aimed at stimulating the antitumor immune response or alleviating the immunosuppression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bulletin du Cancer - Volume 103, Supplement 1, November 2016, Pages S127-S131
Journal: Bulletin du Cancer - Volume 103, Supplement 1, November 2016, Pages S127-S131
نویسندگان
Jeanne Galaine, Yann Godet, Olivier Adotévi,