Carboplatin and Hypofractionated Accelerated Radiotherapy: A Dose Escalation Study of an Outpatient Chemoradiation Schedule for Squamous Cell Carcinoma of the Head and Neck

Carboplatin with concurrent hypofractionated accelerated radiotherapy is feasible for patients with advanced SCCHN and good performance status. The recommended phase II dose of carboplatin given in week 1 and week 4 with 55 Gy in 20 fractions is AUC 4.5.