It’s All in the Brain: A Review of Available Functional Genomic Annotations

What makes the molecular study of psychiatric and other neurological conditions particularly challenging compared with other complex traits is the difficulty of accessing the relevant tissue. The Encyclopedia of DNA Elements (ENCODE) project was one of the earliest producers of brain-derived epigenetic functional genomic data, albeit initially from only two cancerous brain cell lines for a limited number of epigenetic marks. It has only been in very recent years that such data from human brain tissue have been made available from various sources. Yet, these data are scattered throughout the literature with no central organization. This review summarizes the availability and accessibility of brain epigenetic and functional genomic data as a single resource to allow investigators to easily access available brain annotations and thus incorporate this wealth of information into their research to make important advances in the field of neuroscience.