کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5720980 1608024 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Archival ReportDistinct Responses to Predictable and Unpredictable Threat in Anxiety Pathologies: Effect of Panic Attack
ترجمه فارسی عنوان
گزارش بایگانی پاسخ های متفاوتی به تهدید پیش بینی شده و غیر قابل پیش بینی در آسیب های اضطرابی: اثر حملات هراس
کلمات کلیدی
اضطراب، اختلال اضطراب، ترس حمله وحشت پیش بینی پذیری، وحشت زده شدن،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی

BackgroundDelineating specific clinical phenotypes of anxiety disorders is a crucial step toward better classification and understanding of these conditions. The present study sought to identify differential aversive responses to predictable and unpredictable threat of shock in healthy comparisons and in nonmedicated anxiety patients with and without a history of panic attacks (PAs).MethodsIn this study, 143 adults (72 healthy control subjects; 71 patients with generalized, social, or both generalized and social anxiety disorders, 24 with and 47 without PAs) were exposed to three conditions: 1) predictable shocks signaled by a cue, 2) unpredictable shocks, and 3) no shock. Startle magnitude was used to assess aversive responses.ResultsAcross disorders, a history of PAs was specifically associated with hypersensitivity to unpredictable threat. By disorder, social anxiety disorder was associated with hypersensitivity to predictable threat, whereas generalized anxiety disorder was associated with exaggerated baseline startle.ConclusionsThese results identified three physiological patterns. The first is hypersensitivity to unpredictable threat in individuals with PAs. The second is hypersensitivity to predictable threat, which characterizes social anxiety disorder. The third is enhanced baseline startle in generalized anxiety disorder, which may reflect propensity for self-generated anxious thoughts in the absence of imminent danger. These results inform current thinking by linking specific clinical features to particular physiology profiles.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging - Volume 2, Issue 7, October 2017, Pages 575-581
نویسندگان
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