Archival ReportBrain Volume Correlates With Duration of Abstinence From Substance Abuse in a Region-Specific and Substance-Specific Manner

BackgroundHuman neuroimaging studies indicate that the loss of brain volume associated with substance abuse may be recovered during abstinence. Subcortical and prefrontal cortical regions involved in reward and decision making are among the regions most consistently implicated in damage and recovery from substance abuse, but the relative capacities of these different brain regions to recover volume during abstinence remains unclear, and it is unknown whether recovery capacities depend on the substance that was abused.MethodsVoxel-based morphometry was performed in a prison inmate sample (N = 107) of long-term abstinent former regular users (FRUs) and former light users of alcohol, cocaine, and cannabis. Cross-sectional indicators of volume recovery were operationalized as 1) positive correlation between abstinence duration and volume in FRUs and 2) absence of lower volume in FRUs compared with former light users.ResultsIn FRUs of alcohol, abstinence duration positively correlated with volume in subcortical regions (particularly the putamen and amygdala) but not prefrontal regions; lower prefrontal, but not subcortical, volume was observed in FRUs compared with former light users. In FRUs of cocaine, abstinence duration positively correlated with volume in both subcortical regions (particularly the nucleus accumbens) and prefrontal regions; lower volume was not observed in either subcortical or prefrontal regions in FRUs. In FRUs of cannabis, abstinence duration positively correlated with subcortical, but not prefrontal, volume; lower prefrontal, but not subcortical, volume was observed in FRUs.ConclusionsSubcortical structures displayed indicators of volume recovery across FRUs of all three substances, whereas prefrontal regions displayed indicators of volume recovery only in FRUs of cocaine.