کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5736713 | 1613774 | 2017 | 51 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Functional perturbation of forebrain principal neurons reveals differential effects in novel and well-learned tasks
ترجمه فارسی عنوان
اختلال عملکردی نورونهای اصلی پیشانی اثرات متفاوتی را در کارهای رمان و به خوبی آموخته است
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کلمات کلیدی
NBTISHAMYGGIRKMWMaCSFCaMKIIDMSDREADDEPMTTADTPIACUCATDPFCBCIPEPSP - epspiIn situ hybridization - Hybridization در محلdorsomedial striatum - striatum dorsomedialAmygdala - آمیگدال، بادامهACh - آهAcetylcholine - استیل کولینimm - انحصارrepeated measures - اندازه گیری های مکررcon - باelevated plus maze - بالا به همراه پیچ و خمnitro blue tetrazolium - تترازولیم نیترو آبیTetracycline transactivator - تتراسیکلین ترانسکتیویتورanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceDigoxygenin - دیگوکسینژینInstitutional Animal Care and Use Committee - سازمان مراقبت و مراقبت از حیواناتTRE - سهDIG - شماtetracycline response element - عنصر پاسخ تتراسایکلینprefrontal cortex - قشر prefrontalMorris water maze - ماز آب آب موریسartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیpyramidal neuron - نورون هرمیHippocampus - هیپوکامپ polymerase chain reaction - واکنش زنجیره ای پلیمرازPCR - واکنش زنجیرهٔ پلیمرازexcitatory postsynaptic potential - پتانسیل پست سیناپتی هیجان انگیزPVC - پلیوینیل کلراید یا پیویسیPolyvinyl chloride - کلرید پلی وینیلSpatial learning and memory - یادگیری فضایی و حافظه
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Neural circuits in mammalian brains consist of large numbers of different cell types having different functional properties. To better understand the separate roles of individual neuron types in specific aspects of spatial learning and memory, we perturbed the function of principal neurons in vivo during maze performance or in hippocampal slices during recording of evoked excitatory synaptic potentials. Transgenic mice expressing the Drosophila allatostatin receptor (AlstR) in cortical and hippocampal pyramidal cells were tested on an elevated plus maze, in a Y-maze, and in the Morris water maze. Relative to a control cohort, AlstR-positive mice treated with allatostatin exhibited no difference in open arm dwell time on the elevated plus maze or total number of arm entries in a Y-maze, but displayed reduced spontaneous alternation. When animals received massed or spaced training trials in the Morris water maze, and the peptide was delivered prior to an immediate probe, no effects on performance were observed. When the peptide was delivered during a probe trial performed 24Â h after seven days of spaced training, allatostatin delivery to AlstR positive mice enhanced direct navigation to the escape platform. Combined, these results suggest that cortical and hippocampal pyramidal neurons are required during spatial decision-making in a novel environment and compete with other neural systems after extended training in a long-term reference memory task. In hippocampal slices collected from AlstR positive animals, allatostatin delivery produced frequency dependent alterations in the Schaffer collateral fiber volley (attenuated accommodation at 100Â Hz) and excitatory postsynaptic potential (attenuated facilitation at 5Â Hz). Combined, the neural and behavioral discoveries support the involvement of short-term plasticity of Schaffer collateral axons and synapses during exploration of a novel environment and during initial orientation to a goal in a well-learned setting.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1671, 15 September 2017, Pages 1-13
Journal: Brain Research - Volume 1671, 15 September 2017, Pages 1-13
نویسندگان
Emily T. Stoneham, Daniel G. McHail, Katelyn N. Boggs, Sarah H. Albani, Jason A. Carty, Rebekah C. Evans, Kelly A. Hamilton, Victoria M. Saadat, Samanza Hussain, Maggie E. Greer, Theodore C. Dumas,