کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5741184 1617057 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Time to change perspectives on HPV in oropharyngeal cancer. A systematic review of HPV prevalence per oropharyngeal sub-site the last 3 years
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Time to change perspectives on HPV in oropharyngeal cancer. A systematic review of HPV prevalence per oropharyngeal sub-site the last 3 years
چکیده انگلیسی

ObjectivesHuman papillomavirus (HPV) as a risk factor in oropharyngeal squamous cell carcinoma (OPSCC) is well established. However, accumulating data imply that the OPSCC concept is too unspecific with regard to HPV prevalence and clinical importance. To further study the role of HPV in OPSCC by sub-site, a systematic review and meta-analysis was performed.Material and methodPubMed was searched and all studies reporting HPV data (p16/HPV DNA/RNA) in both “lymphoepithelial associated” (i.e. tonsillar and base of tongue cancer; TSCC and BOTSCC respectively) and “non-lymphoepithelial” (“other” OPSCC) OPSCC were included. Pooled odds ratios by HPV detection method were analysed using a random effects model.ResultsIn total, 58 unique patient cohorts were identified. Total HPV prevalence in TSCC/BOTSCC was 56%, 95%CI: 55-57% (59%, 95%CI: 58-60% for TSCC only) as compared to 19%, 95%CI: 17-20%, in “other” OPSCC. Significant association of HPV to TSCC/BOTSCC vs. “other” OPSCC was observed no matter HPV detection method used, but statistical homogeneity was only observed when studies using algorithm based HPV detection were pooled.ConclusionHPV prevalence differs markedly between OPSCC sub-sites and while the role of HPV in TSCC/BOTSCC is strong, the role in “other” OPSCC is more uncertain and needs further evaluation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Papillomavirus Research - Volume 4, December 2017, Pages 1-11
نویسندگان
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