Thiamethoxam and picoxystrobin reduce the survival and overload the hepato-nephrocitic system of the Africanized honeybee

Responses of the hepato-nephrocitic system (HNS) from newly emerged workers of Africanized A. mellifera after five days of oral continuous exposure to pesticides. HNS is composed of the fat body, pericardial cells and immune cells along the myogenic region of the dorsal vessel. Hemocytes = representation of the hemocyte number in each experimental group; Fat body = representation of nucleus alterations (level of nuclear branching in trophocytes) and cytoplasmic granules of trophocytes (left) and oenocytes (right); Pericardial cells = representation of the position of the nucleus (in black), cytoplasmic vacuolations (in gray) and grouping of these cells; Dorsal vessel = evidence of the absence of morphological changes but highlights the accumulation of hemocytes in the its lumen in bees from the TXT group; trophocytes and oenocytes; dark droplets in trophocytes = glycogen; grew droplets in trophocytes and oenocytes= vacuoles; bigger dark droplets in oenocytes= granules; small dark spots in oenocytes= granulation.172