کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5746231 1618787 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Qualitative screening for new psychoactive substances in wastewater collected during a city festival using liquid chromatography coupled to high-resolution mass spectrometry
ترجمه فارسی عنوان
غربالگری کیفی برای مواد روانگردان جدید در فاضلاب جمع آوری شده در جشنواره شهر با استفاده از کروماتوگرافی مایع همراه با طیف سنجی جرم با وضوح بالا
کلمات کلیدی
اپیدمیولوژی مبتنی بر فاضلاب، سوء مصرف مواد مخدر، داروساز، طیف سنجی جرم با وضوح بالا، غربالگری مشکوک،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
چکیده انگلیسی


- Wastewater collected during city-wide festival to track recreational substances use.
- Combination of independent and dependent data acquisition with LC-HRMS.
- Qualitative screening and reporting hits of NPS is more useful.
- Results suggest prevalence of classical drugs and low NPS use.

The inclusion of new psychoactive substances (NPS) in the wastewater-based epidemiology approach presents challenges, such as the reduced number of users that translates into low concentrations of residues and the limited pharmacokinetics information available, which renders the choice of target biomarker difficult. The sampling during special social settings, the analysis with improved analytical techniques, and data processing with specific workflow to narrow the search, are required approaches for a successful monitoring. This work presents the application of a qualitative screening technique to wastewater samples collected during a city festival, where likely users of recreational substances gather and consequently higher residual concentrations of used NPS are expected. The analysis was performed using liquid chromatography coupled to high-resolution mass spectrometry. Data were processed using an algorithm that involves the extraction of accurate masses (calculated based on molecular formula) of expected m/z from an in-house database containing about 2,000 entries, including NPS and transformation products. We positively identified eight NPS belonging to the classes of synthetic cathinones, phenethylamines and opioids. In addition, the presence of benzodiazepine analogues, classical drugs and other licit substances with potential for abuse was confirmed. The screening workflow based on a database search was useful in the identification of NPS biomarkers in wastewater. The findings highlight the specific classical drugs and low NPS use in the Netherlands. Additionally, meta-chlorophenylpiperazine (mCPP), 2,5-dimethoxy-4-bromophenethylamine (2C-B), and 4-fluoroamphetamine (FA) were identified in wastewater for the first time.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 184, October 2017, Pages 1186-1193
نویسندگان
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