کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5800091 1555353 2015 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Differential effects of alloherpesvirus CyHV-3 and rhabdovirus SVCV on apoptosis in fish cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Differential effects of alloherpesvirus CyHV-3 and rhabdovirus SVCV on apoptosis in fish cells
چکیده انگلیسی


- CyHV-3 inhibits the apoptotic process in vivo and in vitro.
- SVCV induces apoptosis-related gene expression in vitro.
- Similar cellular apoptosis-related anti-host strategies exist among Herpesviridae and Alloherpesviridae.

Whilst Herpesviridae, which infect higher vertebrates, actively influence host immune responses to ensure viral replication, it is mostly unknown if Alloherpesviridae, which infect lower vertebrates, possess similar abilities. An important antiviral response is clearance of infected cells via apoptosis, which in mammals influences the outcome of infection. Here, we utilise common carp infected with CyHV-3 to determine the effect on the expression of genes encoding apoptosis-related proteins (p53, Caspase 9, Apaf-1, IAP, iNOS) in the pronephros, spleen and gills. The influence of CyHV-3 on CCB cells was also studied and compared to SVCV (a rhabdovirus) which induces apoptosis in carp cell lines. Although CyHV-3 induced iNOS expression in vivo, significant induction of the genetic apoptosis pathway was only seen in the pronephros. In vitro CyHV-3 did not induce apoptosis or apoptosis-related expression whilst SVCV did stimulate apoptosis. This suggests that CyHV-3 possesses mechanisms similar to herpesviruses of higher vertebrates to inhibit the antiviral apoptotic process.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Microbiology - Volume 176, Issues 1–2, 23 March 2015, Pages 19-31
نویسندگان
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