کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5800811 | 1555360 | 2014 | 8 صفحه PDF | دانلود رایگان |
- Testing the efficacy of a currently used vaccine against more recent viruses.
- Protection level against old and recent NDV isolates was dramatically low.
- No differences in protection when broilers were challenged with different viruses.
- Susceptibility of poultry is the result of poor ND vaccination practices.
Newcastle disease (ND) is a severe threat to the poultry industry and is caused by virulent strains of Newcastle disease virus (NDV). Many countries maintain a vaccination policy, but NDV is rapidly evolving as shown by the discovery of several new genotypes in the last decades. We tested the efficacy of the currently used classical commercial ND vaccine based on the genotype II strain VG/GA, applied under standard field conditions, against outbreak strains. Field vaccinated broilers were challenged with four different viruses belonging to genotype II, V or VII. A large proportion of field vaccinated broilers showed suboptimal immunity and the protection level against early and recent NDV isolates was dramatically low. Furthermore, there were no significant differences in protection afforded by a genotype II vaccine against a genotype II virus challenge compared to a challenge with viruses belonging to the other genotypes. This study suggests that the susceptibility of vaccinated poultry to NDV infection is not the result of vaccine mismatch, but rather of poor vaccination practices.
Journal: Veterinary Microbiology - Volume 172, Issues 1â2, 6 August 2014, Pages 100-107