کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5818857 1557337 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pharmaceutical nanotechnologyDevelopment of fluorous lipid-based nanobubbles for efficiently containing perfluoropropane
ترجمه فارسی عنوان
فناوری نانو فناوری دارویی توسعه نانوبوبلهای مبتنی بر لیپید فلوراید برای کارآمد کردن پرفرولو پروپان
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

Nano-/microbubbles are expected not only to function as ultrasound contrast agents but also as ultrasound-triggered enhancers in gene and drug delivery. Notably, nanobubbles have the ability to pass through tumor vasculature and achieve passive tumor targeting. Thus, nanobubbles would be an attractive tool for use as ultrasound-mediated cancer theranostics. However, the amounts of gas carried by nanobubbles are generally lower than those carried by microbubbles because nanobubbles have inherently smaller volumes. In order to reduce the injection volume and to increase echogenicity, it is important to develop nanobubbles with higher gas content. In this study, we prepared 5 kinds of fluoro-lipids and used these reagents as surfactants to generate “Bubble liposomes”, that is, liposomes that encapsulate nanobubbles such that the lipids serve as stabilizers between the fluorous gas and water phases. Bubble liposome containing 1-stearoyl-2-(18,18-difluoro)stearoyl-sn-glycero-3-phosphocholine carried 2-fold higher amounts of C3F8 compared to unmodified Bubble liposome. The modified Bubble liposome also exhibited increased echogenicity by ultrasonography. These results demonstrated that the inclusion of fluoro-lipid is a promising tool for generating nanobubbles with increased efficiency of fluorous gas carrier.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 487, Issues 1–2, 20 June 2015, Pages 64-71
نویسندگان
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