کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5818971 1557338 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pharmaceutical nanotechnologyNanomechanical testing technique for millimeter-sized and smaller molecular crystals
ترجمه فارسی عنوان
فناوری نانو فناوری داروسازی تکنیک تست نانو تکنیک برای بلورهای مولکولی کوچک و کوچکتر
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

Large crystals are used as a control for the development of a mounting and nanoindentation testing technique for millimeter-sized and smaller molecular crystals. Indentation techniques causing either only elastic or elastic-plastic deformation produce similar results in assessing elastic modulus, however, the elastic indents are susceptible to surface angle and roughness effects necessitating larger sample sizes for similar confidence bounds. Elastic-plastic indentations give the most accurate results and could be used to determine the different elastic constants for anisotropic materials by indenting different crystal faces, but not by rotating the indenter about its axis and indenting the same face in a different location. The hardness of small and large crystals is similar, suggesting that defect content probed in this study is similar, and that small crystals can be compared directly to larger ones. The Young's modulus and hardness of the model test material, griseofulvin, are given for the first time to be 11.5 GPa and 0.4 GPa respectively.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 486, Issues 1–2, 30 May 2015, Pages 324-330
نویسندگان
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