کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5819144 | 1557349 | 2014 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Pharmaceutical nanotechnologyOil-enriched, ultra-small nanostructured lipid carriers (usNLC): A novel delivery system based on flip-flop structure Pharmaceutical nanotechnologyOil-enriched, ultra-small nanostructured lipid carriers (usNLC): A novel delivery system based on flip-flop structure](/preview/png/5819144.png)
For the development of ultra-small NLC (usNLC) the determination of the required HLB (hydrophilic lipophilic balance) was found to be a suitable method, i.e., usNLC with a size below 50Â nm were obtained by this method. Loading with 5% (w/w) coenzyme Q10 (Q10) led to usNLC with a size of about 85Â nm. In comparison to classical NLC with a size of 230Â nm and a nanoemulsion with similar size, the Q10 loaded usNLC show a higher release, a higher antioxidant capacity, and a better skin penetration for Q10. The reason for this is a flip-flop core-shell structure of the lipid matrix, i.e., the oil with dissolved active is surrounding the solid lipid based core. As the flip-flop structure was probably achieved by admixing high contents of liquid lipid, oil enriched usNLC might represent a novel and promising carrier system for the improved delivery of lipophilic actives.
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Journal: International Journal of Pharmaceutics - Volume 477, Issues 1â2, 30 December 2014, Pages 227-235