کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5819202 | 1557354 | 2014 | 8 صفحه PDF | دانلود رایگان |
The purpose of this study was to evaluate the feasibility of ion-exchange fiber ZB-1 as a novel carrier in oral taste-masked mucoadhesive sustained-release suspensions. Propranolol (PPN) hydrochloride was selected as a model drug with good water solubility, short half life and bitter taste. The PPN-fiber complexes (PF) were prepared by a batch process and coated with Eudragit® RS100. Gamma scintigraphy was performed on fasted volunteers revealed about 30% ZB-1 and more than 50% coated ZB-1 were still remaining in the stomach at 6Â h. In vitro results showed the releases of PF and coated PPN-fiber complexes (C-PF) were sustained. The release, drug content and particle size of C-PF were influenced by coat to core ratio, concentration of coating material and rotation rate. The suspension was stable after standing for 30 days in 0.5% Carbopol® with no release rate and taste changed. The administration of C-PF suspension to rats resulted a significant different (PÂ <Â 0.05) improvement of the plasma drug level and prolongation of the release. However, because of the burst effect, the Cmax values of PF suspension didn't differ from drug solution (PÂ >Â 0.05). Furthermore, a linear relationship between in vitro dissolution and in vivo absorption was observed.
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Journal: International Journal of Pharmaceutics - Volume 472, Issues 1â2, 10 September 2014, Pages 74-81