کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5819307 1557355 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lecithin-linker formulations for self-emulsifying delivery of nutraceuticals
ترجمه فارسی عنوان
فرمولاسیون لسیتین-لینکر برای تحویل مواد مغذی مصرف کننده به خودی خود
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی


- Lecithin-linker microemulsions were optimized to form single phase systems with intestinal fluid.
- Lecithin-linkers-oil (with the solubilized drug) can be diluted up to 500 times with intestinal fluid.
- The diluted systems produce stable emulsions with 100-200 nm drop size.
- The emulsions drops irreversible permeate to the excised intestine.

Lecithin-linker microemulsions are formulations produced with soybean lecithin in combination with a highly lipophilic (lipophilic linker) and highly hydrophilic (hydrophilic linkers) surfactant-like additives. In this work, lecithin-linker systems were formulated to produce self-emulsifying delivery systems for β-carotene and β-sitosterol. The concentration of the lipophilic linker, sorbitan monooleate, was adjusted to minimize the formation of liquid crystals. The concentration of hydrophilic linkers, decaglyceryl caprylate/caprate and PEG-6-caprylic/capric glycerides, was gradually increased (scanned) until single phase clear microemulsions were obtained. For these scans, the oil (ethyl caprate) to water ratio was set to 1. The single phase, clear microemulsions were diluted with fed-state simulated intestinal fluid (FeSSIF) and produced stable emulsions, with drop sizes close to 200 nm. Using pseudo-ternary phase diagrams to evaluate the process of dilution of microemulsion preconcentrates (mixtures of oil, lecithin and linkers with little or no water) with FeSSIF, it was determined that self-emulsifying systems are obtained when the early stages of the dilution produce single phase microemulsions. If liquid crystals or multiple phase systems are obtained during those early stages, then the emulsification yields unstable emulsions with large drop sizes. An in vitro permeability study conducted using a Flow-Thru Dialyzer revealed that stable emulsions with drop sizes of 150-300 nm produce large and irreversible permeation of β-carotene to sheep intestine. On the other hand, unstable emulsions produced without the linker combination separated in the dialyzer chamber.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 471, Issues 1–2, 25 August 2014, Pages 92-102
نویسندگان
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