کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5819362 1557355 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comparison of ethosomes and liposomes for skin delivery of psoralen for psoriasis therapy
ترجمه فارسی عنوان
مقایسه اتوزوم ها و لیپوزوم ها برای تحویل پوست پرورش دهنده به درمان پسوریازیس
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

Recent reports have indicated that psoriasis may be caused by malfunctioning dermal immune cells, and psoralen ultraviolet A (PUVA) is an effective treatment for this chronic disease. However, conventional topical formulations achieve poor drug delivery across patches of psoriasis to their target sites. The present study describes the development of a novel psoralen transdermal delivery system employing ethosomes, flexible vesicles that can penetrate the stratum corneum and target deep skin layers. An in vitro skin permeation study showed that the permeability of psoralen-loaded ethosomes was superior to that of liposomes. Using ethosomes, psoralen transdermal flux and skin deposition were 38.89 ± 0.32 μg/cm2/h and 3.87 ± 1.74 μg/cm2, respectively, 3.50 and 2.15 times those achieved using liposomes, respectively. The ethosomes and liposomes were found to be safe following daily application to rat skin in vivo, for 7 days. The ethosomes showed better biocompatibility with human embryonic skin fibroblasts than did an equivalent ethanol solution, indicating that the phosphatidylcholine present in ethosome vesicles improved their biocompatibility. These findings indicated that ethosomes could potentially improve the dermal and transdermal delivery of psoralen and possibly of other drugs requiring deep skin delivery.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 471, Issues 1–2, 25 August 2014, Pages 449-452
نویسندگان
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