کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5819440 1557355 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rapid communicationContinuous manufacturing of solid lipid nanoparticles by hot melt extrusion
ترجمه فارسی عنوان
ارتباطات سریع ارتباط بی وقفه تولید نانوذرات لیپید جامد با اکستروژن ذوب داغ
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

Solid lipid nanoparticles (SLN) can either be produced by hot homogenization of melted lipids at higher temperatures or by a cold homogenization process. This paper proposes and demonstrates the formulation of SLN for pharmaceutical applications by combining two processes: hot melt extrusion (HME) technology for melt-emulsification and high-pressure homogenization (HPH) for size reduction. This work aimed at developing continuous and scalable processes for SLN by mixing a lipid and aqueous phase containing an emulsifier in the extruder barrel at temperatures above the melting point of the lipid and further reducing the particle size of emulsion by HPH linked to HME in a sequence. The developed novel platform demonstrated better process control and size reduction compared to the conventional process of hot homogenization (batch process). Varying the process parameters enabled the production of SLN below 200 nm (for 60 mg/ml lipid solution at a flow rate of 100 ml/min). Among the several process parameters investigated, the lipid concentration, residence time and screw design played major roles in influencing the size of the SLN. This new process demonstrates the potential use of hot melt extrusion technology for continuous and large-scale production of SLN.

Schematic representation of continuous preparation of SLNs using hot melt extrusion connected to a high pressure homogenizer.122

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 471, Issues 1–2, 25 August 2014, Pages 153-156
نویسندگان
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