کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5819650 1557362 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of the resistance of a geopolymer-based drug delivery system to tampering
ترجمه فارسی عنوان
ارزیابی مقاومت یک سیستم تحویل دارویی مبتنی بر ژئوپلیمر به جاسوسی
کلمات کلیدی
فرمولاسیون، مقاومت در برابر دستکاری اپیوئیدها، سو استفاده کردن، تحویل داروی خوراکی، انتشار کنترل شده،
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

Tamper-resistance is an important property of controlled-release formulations of opioid drugs. Tamper-resistant formulations aim to increase the degree of effort required to override the controlled release of the drug molecules from extended-release formulations for the purpose of non-medical use. In this study, the resistance of a geopolymer-based formulation to tampering was evaluated by comparing it with a commercial controlled-release tablet using several methods commonly used by drug abusers. Because of its high compressive strength and resistance to heat, much more effort and time was required to extract the drug from the geopolymer-based formulation. Moreover, in the drug-release test, the geopolymer-based formulation maintained its controlled-release characteristics after milling, while the drug was released immediately from the milled commercial tablets, potentially resulting in dose dumping. Although the tampering methods used in this study does not cover all methods that abuser could access, the results obtained by the described methods showed that the geopolymer matrix increased the degree of effort required to override the controlled release of the drug, suggesting that the formulation has improved resistance to some common drug-abuse tampering methods. The geopolymer matrix has the potential to make the opioid product less accessible and attractive to non-medical users.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 465, Issues 1–2, 25 April 2014, Pages 169-174
نویسندگان
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