کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5819656 | 1557362 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Application of imaging based tools for the characterisation of hollow spray dried amorphous dispersion particles
ترجمه فارسی عنوان
استفاده از ابزارهای تصویربرداری برای توصیف ذرات پراکندگی آمورف خشک شده اسپری توخالی
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کلمات کلیدی
خشک کردن اسپری، اسپری پراکندگی خشک، خواص پودر، تراکم، تصویربرداری، داروها،
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
چکیده انگلیسی
The aim of this study was to investigate novel approaches to determine spray dried dispersion (SDD) specific particle characteristics through the use of imaging based technologies. The work demonstrates approaches that can be applied in order to access quantitative approximations for powder characteristics for hollow particles, such as SDD.Cryo-SEM has been used to measure the solid volume fraction and/or particle density of SDD particles. Application of this data to understand the impact of spray drying process conditions on SDD powder properties, and their impact on processability and final dosage form quality were investigated.The use of data from a Morphologi G3 image based particle characterisation system was also examined in order to explain both the propensity and extent of attrition within a series of SDD samples, and also demonstrate the use of light transmission data to assess the relative wall thickness of SDD particles.Such approaches demonstrate a means to access potentially useful information that can be linked to important particle characteristics for SDD materials which, in addition to the standard bulk powder measurements such as bulk density, may enable a better understanding of such materials and their impact on downstream processability and final dosage form acceptability.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 465, Issues 1â2, 25 April 2014, Pages 210-217
Journal: International Journal of Pharmaceutics - Volume 465, Issues 1â2, 25 April 2014, Pages 210-217
نویسندگان
John F. Gamble, Ana P. Ferreira, Mike Tobyn, Lynn DiMemmo, Kyle Martin, Neil Mathias, Richard Schild, Balvinder Vig, John M. Baumann, Stacy Parks, Mike Ashton,