کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5820072 1557373 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewDelivery of ibuprofen to the skin
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
ReviewDelivery of ibuprofen to the skin
چکیده انگلیسی

Ibuprofen (IBU) has been available as a topical skin preparation for more than two decades. Its primary indication is for the relief of pain and inflammation in rheumatic disease and other musculoskeletal conditions. This article reviews the various formulation strategies which have been investigated for percutaneous IBU delivery to date. The focus is on studies which have been conducted with IBU in the free base form on human or porcine skin as data from other species are known to overestimate likely permeation in man. Emerging technologies for enhanced dermal delivery of IBU are considered including methods which require physical disruption of the membrane. The role of biophysical techniques such as Confocal Raman Spectroscopy in the rational development of IBU formulations is also discussed.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 457, Issue 1, 30 November 2013, Pages 9-13
نویسندگان
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