کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5820696 1557399 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New polymer-halloysite hybrid materials-potential controlled drug release system
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
New polymer-halloysite hybrid materials-potential controlled drug release system
چکیده انگلیسی

New hybrid materials based on a natural host (halloysite), biodegradable polymer (poly(vinyl alcohol)) and diphenhydramine hydrochloride as drug were synthesized and tested as a potential controlled drug delivery system.The formation of these hybrid materials was proved using different characterization methods like Spectroscopic techniques (FTIR, XPS and UV-vis), thermogravimetrical analysis and scanning electron microscopy (SEM). The hybrid materials exhibit different features regarding the drug release. In vitro drug release tests showed that there are several factors which exhibit a strong influence on the drug release rate. Thus the initial drug concentration used at the hybrid materials synthesis, the presence of a polymer in the hybrid composition and the pH value of the release medium are the most important factors.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 436, Issues 1–2, 15 October 2012, Pages 568-573
نویسندگان
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