کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5820696 | 1557399 | 2012 | 6 صفحه PDF | دانلود رایگان |

New hybrid materials based on a natural host (halloysite), biodegradable polymer (poly(vinyl alcohol)) and diphenhydramine hydrochloride as drug were synthesized and tested as a potential controlled drug delivery system.The formation of these hybrid materials was proved using different characterization methods like Spectroscopic techniques (FTIR, XPS and UV-vis), thermogravimetrical analysis and scanning electron microscopy (SEM). The hybrid materials exhibit different features regarding the drug release. In vitro drug release tests showed that there are several factors which exhibit a strong influence on the drug release rate. Thus the initial drug concentration used at the hybrid materials synthesis, the presence of a polymer in the hybrid composition and the pH value of the release medium are the most important factors.
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Journal: International Journal of Pharmaceutics - Volume 436, Issues 1â2, 15 October 2012, Pages 568-573