کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5820750 | 1557399 | 2012 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Screening paediatric rectal forms of azithromycin as an alternative to oral or injectable treatment
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
The aim of this study was to identify a candidate formulation for further development of a home or near-home administrable paediatric rectal form of a broad-spectrum antibiotic - specially intended for (emergency) use in tropical rural settings, in particular for children who cannot take medications orally and far from health facilities where injectable treatments can be given. Azithromycin, a broad-spectrum macrolide used orally or intravenously for the treatment of respiratory tract, skin and soft tissue infections, was selected because of its pharmacokinetic and therapeutic properties. Azithromycin in vitro solubility and stability in physiologically relevant conditions were studied. Various pharmaceutical forms, i.e. rectal suspension, two different rectal gels, polyethylene glycol (PEG) suppository and hard gelatin capsule (HGC) were assessed for in vitro dissolution and in vivo bioavailability in the rabbit. Azithromycin PEG suppository appears to be a promising candidate.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 436, Issues 1â2, 15 October 2012, Pages 624-630
Journal: International Journal of Pharmaceutics - Volume 436, Issues 1â2, 15 October 2012, Pages 624-630
نویسندگان
Tina Kauss, Karen Gaudin, Alexandra Gaubert, Boubakar Ba, Serena Tagliaferri, Fawaz Fawaz, Jean-Louis Fabre, Jean-Michel Boiron, Xavier Lafarge, Nicholas J. White, Piero L. Olliaro, Pascal Millet,