کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5820914 | 1557411 | 2012 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Pharmaceutical NanotechnologyNovel superparamagnetic iron oxide nanoparticles for tumor embolization application: Preparation, characterization and double targeting Pharmaceutical NanotechnologyNovel superparamagnetic iron oxide nanoparticles for tumor embolization application: Preparation, characterization and double targeting](/preview/png/5820914.png)
The goal of this study was to develop novel embolic nanoparticles for targeted tumor therapy with dual targeting: magnetic field-guided and peptide-directed targeting. The embolic nanoparticles SP5.2/tTF-OCMCs-SPIO-NPs were prepared by surface-modifying of superparamagnetic iron oxide nanoparticles (SPIO-NPs) with o-carboxymethylchitosans (OCMCs) and SP5.2/tTF (SP5.2: a peptide binding to VEGFR-1; tTF: truncated tissue factor) to improve their stability and to target over-expressing VEGFR-1 cells. The physicochemical characterization results showed that the OCMCs-SPIO-NPs have a spherical or ellipsoidal morphology with an average diameter of 10-20Â nm. And they possess magnetism with a saturation magnetization of 66.1Â emu/g, negligible coercivity and remanence at room temperature. In addition, the confocal microscopy, Prussian blue staining and FX activation analysis respectively demonstrated the peptide-directed targeting, magnetic field-guided targeted and blood coagulation activity of the SP5.2/tTF-OCMCs-SPIO-NPs. These properties separately belong to SP5.2, Fe3O4 and tTF moieties of the SP5.2/tTF-OCMCs-SPIO-NPs. Thus these SP5.2/tTF-OCMCs-SPIO-NPs with double-targeting function should have a potential application in embolization therapy of tumor blood vessels.
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Journal: International Journal of Pharmaceutics - Volume 426, Issues 1â2, 15 April 2012, Pages 248-255