کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5822190 1557834 2014 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Accessory proteins of SARS-CoV and other coronaviruses
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Accessory proteins of SARS-CoV and other coronaviruses
چکیده انگلیسی
The huge RNA genome of SARS coronavirus comprises a number of open reading frames that code for a total of eight accessory proteins. Although none of these are essential for virus replication, some appear to have a role in virus pathogenesis. Notably, some SARS-CoV accessory proteins have been shown to modulate the interferon signaling pathways and the production of pro-inflammatory cytokines. The structural information on these proteins is also limited, with only two (p7a and p9b) having their structures determined by X-ray crystallography. This review makes an attempt to summarize the published knowledge on SARS-CoV accessory proteins, with an emphasis on their involvement in virus-host interaction. The accessory proteins of other coronaviruses are also briefly discussed. This paper forms part of a series of invited articles in Antiviral Research on “From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses” (see Introduction by Hilgenfeld and Peiris (2013)).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Antiviral Research - Volume 109, September 2014, Pages 97-109
نویسندگان
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