کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5822269 1557835 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Formulation of cidofovir improves the anti-papillomaviral activity of topical treatments in the CRPV/rabbit model
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Formulation of cidofovir improves the anti-papillomaviral activity of topical treatments in the CRPV/rabbit model
چکیده انگلیسی
The results demonstrated that anti-papilloma treatments with topical CDV were greatly enhanced when formulated versus unformulated. Best results were obtained with CDV formulated in cremophor, then in Carbomer 940, and then in DMSO. Further studies indicated that effective formulations led to complete cures of papillomas at dilutions less than 0.3% CDV. These studies together with previous observations demonstrated that unformulated CDV under the same treatment regime required doses of 2% to achieve cures demonstrating that much less compound can be used when properly formulated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Antiviral Research - Volume 108, August 2014, Pages 148-155
نویسندگان
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