SOCS1 abrogates IFN's antiviral effect on hepatitis C virus replication

► Silencing of SOCS1 by shRNA increased the anti-HCV effect of IFN. ► Overexpression of SOCS1 prior to IFN treatment inhibited JAK-STAT signaling pathway. ► SOCS1 negatively regulates IFN signaling during HCV treatment.