Catheterized guinea pigs infected with Ebola Zaire virus allows safer sequential sampling to determine the pharmacokinetic profile of a phosphatidylserine-targeting monoclonal antibody

► Catheterized guinea pigs can be used successfully at high containment. ► Catheterization reduces the requirement for sharps. ► Simultaneous blood samples can easily be collected from guinea pigs. ► Ebola virus infection had no effect on decay profile of a PS-targeting antibody.