Correlation between hepatitis B virus protein and microRNA processor Drosha in cells expressing HBV

► We demonstrated that HBV could down regulate one of miRNA producing protein, Drosha expression. ► We examined the mechanism of HBV regulated Drosha expression. ► HBx may have function in regulated Drosha promoter activity. ► Knockdown of SP1 and AP-2α expressions could partially enhance activity of DGCR8 promoter activity.