کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5823032 1117996 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Phyllaemblicin B inhibits Coxsackie virus B3 induced apoptosis and myocarditis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Phyllaemblicin B inhibits Coxsackie virus B3 induced apoptosis and myocarditis
چکیده انگلیسی
Coxsackie virus B3 (CVB3) is believed to be a major contributor to viral myocarditis since virus-associated apoptosis plays a role in the pathogenesis of experimental myocarditis. In this study, we investigated the in vitro and in vivo antiviral activities of Phyllaemblicin B, the main ellagitannin compound isolated from Phyllanthus emblica, a Chinese herb medicine, against CVB3. Herein we report that Phyllaemblicin B inhibited CVB3-mediated cytopathic effects on HeLa cells with an IC50 value of 7.75 ± 0.15 μg/mL. In an in vivo assay, treatment with 12 mg kg−1 d−1 Phyllaemblicin B reduced cardiac CVB3 titers, decreased the activities of LDH and CK in murine serum, and alleviated pathological damages of cardiac muscle in myocarditic mice. Moreover, Phyllaemblicin B clearly inhibited CVB3-associated apoptosis effects both in vitro and in vivo. These results show that Phyllaemblicin B exerts significant antiviral activities against CVB3. Therefore, Phyllaemblicin B may represent a potential therapeutic agent for viral myocarditis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Antiviral Research - Volume 84, Issue 2, November 2009, Pages 150-158
نویسندگان
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