Activation of mitogen-activated protein kinases by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) plays an important role in macrophage stimulation

This study confirms that DMXAA activates both p38 and ERK1/2 MAPKs through unknown mechanisms. By using selective inhibitors of MAPKs, BIRB796 and FR180204, we confirmed that both p38 and ERK1/2 MAPK play a significant role in regulation of TNF-α and IL-6 protein production induced by DMXAA at the post-transcriptional level.