Purified active lotus plumule (Nelumbo nucifera Gaertn) polysaccharides exert anti-inflammatory activity through decreasing Toll-like receptor-2 and -4 expressions using mouse primary splenocytes

Proved anti-inflammatory mechanisms of LPPS and its purified components F1 and F2 through Toll-like receptor-2 (TLR-2) and TLR-4 pathways using lipopolysaccharide-stimulated mouse primary splenocytes. All of LPPS, F1 and F2 inhibited TLR-2 mRNA expression, however only F2 inhibited TLR-4 mRNA expression.96