کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5841863 1124688 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Review articleThe role of endothelin-1 in the sympathetic nervous system in the heart
ترجمه فارسی عنوان
نقش اندوتلین-1 در سیستم عصبی سمپاتیک در قلب
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

Endothelin-1 (ET1) is a peptide that was initially identified as a strong inductor of vascular contraction. In the last 25 years, there have been several biological processes identified in which ET1 seems to play a critical role. In particular, genetic studies have unveiled that ET1 is important for neuronal development, growth and function. Experimental studies identified ET1 as a regulator of the interaction between sympathetic neurons and cardiac myocytes. This might be of clinical importance since patients suffering from heart failure are characterized by disrupted norepinephrine homeostasis in the heart. This review summarizes the important findings on the role of ET1 for sympathetic neurons and norepinephrine homeostasis in the heart.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 118, Issue 2, 24 November 2014, Pages 165-172
نویسندگان
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