Casted-immobilization downregulates glucocorticoid receptor expression in rat slow-twitch soleus muscle

This study provides evidence that casted-immobilization-induced muscle disuse downregulates GR expression in slow-twitch muscle. These results suggest that muscle disuse suppresses glucocorticoid signals, such as muscle protein breakdown and transcription of the β2-AR gene, via downregulation of GR expression in slow-twitch muscle.