کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5844088 | 1560944 | 2016 | 36 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Primaquine pharmacology in the context of CYP 2D6 pharmacogenomics: Current state of the art
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کلمات کلیدی
In vivo imaging systemIVISCyPG6PDADHMOA8-aminoquinoline - 8-آمینو کینولینROS - ROSaldehyde dehydrogenase - آلدئید دهیدروژنازCytochrome P450 - سیتوکروم پی۴۵۰Pharmacogenomics - فارماکوژنومیکHepatic metabolism - متابولیسم کبدیmonoamine oxidase - مونوآمین اکسیدازها Primaquine - پرایمکینPlasmodium vivax - پلاسمودیوم ویواکسglucose-6-phosphate dehydrogenase - گلوکز 6-فسفات دهیدروژنازReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Primaquine is the only antimalarial drug available to clinicians for the treatment of relapsing forms of malaria. Primaquine development and usage dates back to the 1940s and has been administered to millions of individuals to treat and eliminate malaria infections. Primaquine therapy is not without disadvantages, however, as it can cause life threatening hemolysis in humans with glucose-6-phosphate dehydrogenase (G6PD) deficiency. In addition, the efficacy of primaquine against relapsing malaria was recently linked to CYP 2D6 mediated activation to an active metabolite, the structure of which has escaped definitive identification for over 75Â years. CYP 2D6 is highly polymorphic among various human populations adding further complexity to a comprehensive understanding of primaquine pharmacology. This review aims to discuss primaquine pharmacology in the context of state of the art understanding of CYP 2D6 mediated 8-aminoquinoline metabolic activation, and shed light on the current knowledge gaps of 8-aminoquinoline mechanistic understanding against relapsing malaria.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 161, May 2016, Pages 1-10
Journal: Pharmacology & Therapeutics - Volume 161, May 2016, Pages 1-10
نویسندگان
Sean R. Marcsisin, Gregory Reichard, Brandon S. Pybus,