کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5844214 | 1561029 | 2016 | 9 صفحه PDF | دانلود رایگان |
- Affect of maternal immune activation on white matter neuron pathology was studied.
- Neurons were observed in the white matter of the corpus callosum of the rat brain.
- Some of these white matter neurons contain somatostatin.
- Maternal immune activation increased somatostatin+ white matter neuron density.
- This white matter neuron pathology is similar to that observed in schizophrenia.
Interstitial neurons are located among white matter tracts of the human and rodent brain. Post-mortem studies have identified increased interstitial white matter neuron (IWMN) density in the fibre tracts below the cortex in people with schizophrenia. The current study assesses IWMN pathology in a model of maternal immune activation (MIA); a risk factor for schizophrenia. Experimental MIA was produced by an injection of polyinosinic:polycytidylic acid (PolyI:C) into pregnant rats on gestational day (GD) 10 or GD19. A separate control group received saline injections. The density of neuronal nuclear antigen (NeuN+) and somatostatin (SST+) IWMNs was determined in the white matter of the corpus callosum in two rostrocaudally adjacent areas in the 12 week old offspring of GD10 (n = 10) or GD19 polyI:C dams (n = 18) compared to controls (n = 20). NeuN+ IWMN density trended to be higher in offspring from dams exposed to polyI:C at GD19, but not GD10. A subpopulation of these NeuN+ IWMNs was shown to express SST. PolyI:C treatment of dams induced a significant increase in the density of SST+ IWMNs in the offspring when delivered at both gestational stages with more regionally widespread effects observed at GD19. A positive correlation was observed between NeuN+ and SST+ IWMN density in animals exposed to polyI:C at GD19, but not controls. This is the first study to show that MIA increases IWMN density in adult offspring in a similar manner to that seen in the brain in schizophrenia. This suggests the MIA model will be useful in future studies aimed at probing the relationship between IWMNs and schizophrenia.
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 65, 4 February 2016, Pages 118-126