کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5844346 | 1561040 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Association of gene polymorphisms encoding dopaminergic system components and platelet MAO-B activity with alcohol dependence and alcohol dependence-related phenotypes
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
Catechol-O-methyltransferaseDBHDATVNTRCOMTDRD4dopamine receptor D4MAO-BMonoamine oxidase type BDopamine transporter - انتقال دهنده دوپامینVariable number of tandem repeats - تعداد متغیر تکرارهای tandemdopamine beta-hydroxylase - دوپامین بتا هیدروکسیلازAlcohol dependence - وابستگی الکلیPolymorphisms - پلی مورفیسمSingle nucleotide polymorphism - پلیمورفیسم تک نوکلئوتیدیSNP - چندریختی تک-نوکلئوتید
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Association of gene polymorphisms encoding dopaminergic system components and platelet MAO-B activity with alcohol dependence and alcohol dependence-related phenotypes Association of gene polymorphisms encoding dopaminergic system components and platelet MAO-B activity with alcohol dependence and alcohol dependence-related phenotypes](/preview/png/5844346.png)
چکیده انگلیسی
The present study aimed to evaluate the association of alcohol dependence and alcohol dependence-related phenotypes with platelet monoamine oxidase type B (MAO-B) activity, Val108/158Met of catechol-o-methyltransferase (COMT), variable number of tandem repeats (VNTR) in the third exon of dopamine receptor D4 (DRD4) gene, VNTR in the 3â²-untranslated region of dopamine transporter (DAT) gene, â 1021C/T of dopamine beta-hydroxylase (DBH) and MAO-B intron 13 polymorphisms. The study included 1270 Caucasian men and women of Croatian origin: 690 patients with alcohol dependence and 580 healthy controls. Patients with alcohol dependence were subdivided according to the presence or absence of withdrawal symptoms, aggressive behavior, severity of alcohol dependence, delirium tremens, comorbid depression, suicidal behavior, lifetime suicide attempt and early/late onset of alcohol abuse. The results, corrected for multiple testing, revealed increased platelet MAO-B activity in patients with alcohol dependence, subdivided into those with or without alcohol-related liver diseases, compared to control subjects (P < 0.001). In addition, we found an increased frequency of the COMT Met/Met genotype among suicidal (P = 0.002) and patients who attempted suicide (P < 0.001) and an increased frequency of COMT Val/Val genotype in patients with an early onset of alcohol dependence (P = 0.004). This study provides data from a sample of ethnically homogeneous unrelated Caucasian subjects for future meta-analyses and suggests that the increased platelet MAO-B activity might be used as independent peripheral indicator of alcohol dependence, while COMT Val108/158Met polymorphism is associated with increased suicidality and early onset of alcohol dependence.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 54, 3 October 2014, Pages 321-327
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 54, 3 October 2014, Pages 321-327
نویسندگان
Gordana Nedic Erjavec, Korona Nenadic Sviglin, Matea Nikolac Perkovic, Dorotea Muck-Seler, Tanja Jovanovic, Nela Pivac,