کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5844357 | 1561040 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The potential of neural stem cell transplantation for the treatment of fetal alcohol spectrum disorder
ترجمه فارسی عنوان
پتانسیل پیوند سلول های بنیادی عصبی برای درمان اختلالات طیف الکل جنین
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کلمات کلیدی
N-methyl-d-aspartatehistone H3 lysine 9partial fetal alcohol syndromeH3K9G9aFAETeratogenicityARNDNPCNSCsFASDNMDAPFASFASMSCsc-Myc - c-mychNT - HNTROS - ROSγ-amino-butyric acid - γ-آمینو اسید بوتیریکFetal alcohol effects - اثرات الکل جنینfetal alcohol spectrum disorder - اختلال طیف الکل جنینalcohol-related neurodevelopmental disorder - اختلال نعوظ مرتبط با الکلMRI - امآرآی یا تصویرسازی تشدید مغناطیسیMagnetic resonance imaging - تصویربرداری رزونانس مغناطیسیNeurodegeneration - تولید نوروژنیکposition emission tomography - توموگرافی انتشار موضعیMesenchymal stem cells - سلول های بنیادی مزانشیمیneural progenitor cell - سلول پیشرو عصبیNeural stem cells - سلولهای بنیادی عصبیFetal alcohol syndrome - سندرم جنینی الکلParvalbumin - پاروالبومینPET - پتGABA - گاباReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Fetal alcohol spectrum disorder (FASD) is caused by intrauterine exposure to alcohol and can cause a full range of abnormalities to brain development, as well as long-term sequelae of cognitive, sensory and motor impairments. The incidence is estimated to be as high as 2% to 5% in children born within the US, however the prevalence is even higher in low socioeconomic populations. Despite the various mechanisms thought to explain the etiology of FASD, molecular targets of ethanol toxicity during development are not completely understood. More recent findings explore the role of GABA-A and GABA-B mechanisms, as well as cell death, cell signaling and gene expression malfunctions. Stem cell based therapies have grown exponentially over the last decade, which have lead to novel clinical interventions across many disciplines. Thus, early detailed understanding of the therapeutic potential of stem cell research has provided promising applications across a wide range of illnesses. Consequently, these potential benefits may ultimately lead to a reduced incidence and severity of this highly preventable and prevalent birth defect. It is recognized that stem cell derivations provide unique difficulties and limitations of therapeutic applications. This review will outline the current knowledge, along with the benefits and challenges of stem cell therapy for FASD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 54, 3 October 2014, Pages 149-156
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 54, 3 October 2014, Pages 149-156
نویسندگان
Stephen G. Poulos, William D. Richie, Rahn K. Bailey, Arthur Lee, Ike dela Peña, Paul R. Sanberg, Cesar V. Borlongan,