کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5844371 1561036 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reduced prefrontal activation during a verbal fluency task in Chinese-speaking patients with schizophrenia as measured by near-infrared spectroscopy
ترجمه فارسی عنوان
کاهش فعالیت پیش فرنتن در طی یک وظیفه فلسفی کلامی در بیماران مبتلا به اسکیزوفرنی چینی به وسیله طیف سنجی نزدیک به مادون قرمز
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی
Near-infrared spectroscopy (NIRS) has been applied to examine the possible functional alternations during the performance of cognitive tasks in schizophrenia. With this technique, previous studies have observed that patients with schizophrenia are often associated with reduced brain activation in the prefrontal cortex during the verbal fluency task (VFT) of the English version or the Japanese version. However, it remains unclear whether there is a brain functional impairment in Chinese-speaking patients with schizophrenia. In this study, we designed a Chinese version of the VFT and performed a multichannel NIRS study in a large group of patients with schizophrenia and healthy controls. We investigated brain activation during the task period of the Chinese version of the VFT within a schizophrenia group and a healthy group, respectively, and compared the relative changes between the two groups. Our results confirmed that Chinese-speaking patients with schizophrenia had significantly lower brain activation in the prefrontal cortex and superior temporal cortex when compared with healthy controls. Such findings based on the NIRS data provided us reliable evidences about brain functional deficits in the Chinese-speaking patients with schizophrenia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 58, 3 April 2015, Pages 51-58
نویسندگان
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