کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5844499 | 1561046 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Baseline impulsive choice predicts the effects of nicotine and nicotine withdrawal on impulsivity in rats
ترجمه فارسی عنوان
انتخاب امپدانس مبتنی بر پیش بینی تاثیر نیکوتین و خروج نیکوتین بر تکانشگری در موش صحرایی
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کلمات کلیدی
ITIDelayed rewardsecond(s)AUC - AUCanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceDelay discounting - تخفیف تاخیرMin - حداقلminute(s) - دقایق)hour(s) - ساعت ها)intertrial interval - فاصله بین فضاییarea under the curve - منطقه تحت منحنیWistar rats - موش های صحرایی Wistar
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Impulsive choice, a form of impulsivity, is associated with tobacco smoking in humans. Trait impulsivity may be a vulnerability factor for smoking, or smoking may lead to impulsive behaviors. We investigated the effects of 14-day nicotine exposure (6.32Â mg/kg/day base, subcutaneous minipumps) and spontaneous nicotine withdrawal on impulsive choice in low impulsive (LI) and high impulsive (HI) rats. Impulsive choice was measured in the delayed reward task in which rats choose between a small immediate reward and a large delayed reward. HI and LI rats were selected from the highest and lowest quartiles of the group before exposure to nicotine. In non-selected rats, nicotine or nicotine withdrawal had no effect on impulsive choice. In LI rats, chronic nicotine exposure decreased preference for the large reward with larger effects at longer delays, indicating increased impulsive choice. Impulsive choices for the smaller immediate rewards continued to increase during nicotine withdrawal in LI rats. In HI rats, nicotine exposure and nicotine withdrawal had no effect on impulsive choice, although there was a tendency for decreased preference for the large reward at short delays. These results indicate that nicotine- and nicotine withdrawal-induced increases in impulsive choice depend on trait impulsivity with more pronounced increases in impulsive choice in LI compared to HI subjects. Increased impulsivity during nicotine exposure may strengthen the addictive properties of nicotine and contribute to compulsive nicotine use.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 48, 3 January 2014, Pages 6-13
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 48, 3 January 2014, Pages 6-13
نویسندگان
Hakan Kayir, Svetlana Semenova, Athina Markou,