|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|5844750||1561051||2013||5 صفحه PDF||سفارش دهید||دانلود رایگان|
BackgroundBrain-derived neurotrophic factor (BDNF) has been implicated in the pathophysiology of depression and anxiety, but has not been examined systematically in generalized anxiety disorder (GAD). The objective of this study was to examine the relationship between baseline BDNF level and treatment response in patients with GAD.MethodsPatients (NÂ =Â 168) were from China, met criteria for DSM-IV GAD, had a Hospital Anxiety and Depression Rating Anxiety (HADS-A) subscale score â¥Â 10, and a Sheehan Disability Scale (SDS) global functioning total score â¥Â 12 at baseline. Study design was double-blind therapy for 15Â weeks with duloxetine 60-120Â mg or placebo. Efficacy measures included the HADS-A and Hamilton Anxiety Rating Scale (HAMA) total score. Change from baseline to endpoint for BDNF by treatment group was analyzed using ANCOVA models with baseline BDNF level as a covariate.ResultsNo significant association was found between baseline plasma BDNF levels and anxiety illness severity. Patients who received duloxetine (nÂ =Â 88) had a significantly greater mean increase in plasma BDNF level (957.80Â picograms/ml) compared with patients who received placebo (nÂ =Â 80; 469.93Â pg/mL) (PÂ =Â .007). Patients who met response and remission criteria (with either treatment) had greater mean increases in BDNF at endpoint from baseline (PÂ â¤Â .05) but when compared with nonresponders and nonremitters, respectively, the differences in mean increase were not statistically significant between groups.ConclusionsBDNF levels significantly increased with duloxetine treatment for GAD, but response and remission outcomes were not clearly related to an increase in plasma BDNF level.
âº Brain-derived neurotrophic factor was studied with generalized anxiety disorder. âº 15 week treatment with duloxetine significantly increased plasma BDNF versus placebo. âº Baseline plasma BDNF was not significantly associated with severity of anxiety. âº The increase in plasma BDNF was not associated with response or remission status. âº BDNF responds to treatment in GAD but further research needed for clinical relevance.
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 43, 3 June 2013, Pages 217-221