Sildenafil influences the anticonvulsant activity of vigabatrin and gabapentin in the timed pentylenetetrazole infusion test in mice

► Sildenafil influences convulsive susceptibility. ► Effect of sildenafil on the anticonvulsant potential of gabapentin and vigabatrin was studied. ► Sildenafil enhanced the anticonvulsant activity of gabapentin and vigabatrin. ► Interactions of sildenafil with the studied anticonvulsants were pharmacodynamic.