Association study between Disrupted-in-Schizophrenia-1 (DISC1) and Japanese patients with treatment-resistant schizophrenia (TRS)

► Treatment-resistant schizophrenia can be problematic. ► Disrupted-in-Schizophrenia-1 (DISC1), a candidate susceptibility gene for schizophrenia, and TRS was reported in Caucasian. ► We examined whether DISC1 was also related to Japanese treatment-resistant schizophrenia. ► DISC1 had no apparent degree of association with Japanese patients with schizophrenia as a candidate susceptibility gene for disease per se or TRS.