کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5845821 | 1561157 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Analysis of real-time mixture cytotoxicity data following repeated exposure using BK/TD models
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کلمات کلیدی
NCIBiokineticsNOECNECToxicodynamicsBP2Independent action - اقدام مستقلImpedance - امپدانسbenzophenone-2 - بنزوفنون-2Cell viability - زنده ماندن سلولRepeated dose toxicity - سمیت دوزهای مجزاHepatotoxicity - سمیت کبدConcentration addition - علاوه بر تمرکزNo observed effect concentration - غلظت اثر مشاهده نشدهNo effect concentration - غلظت اثر نداردmixture - مخلوط
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Thanks to impedance metrics, real-time cell viability monitoring for repeated exposure has become possible. We recently constructed biokinetic/toxicodynamic models (BK/TD) to analyze such data (Teng et al., 2015) for three hepatotoxic cosmetic ingredients: coumarin, isoeugenol and benzophenone-2. In the present study, we aim to apply these models to analyze the dynamics of mixture impedance data using the concepts of concentration addition and independent action. Metabolic interactions between the mixture components were investigated, characterized and implemented in the models, as they impacted the actual cellular exposure. Indeed, cellular metabolism following mixture exposure induced a quick disappearance of the compounds from the exposure system. We showed that isoeugenol substantially decreased the metabolism of benzophenone-2, reducing the disappearance of this compound and enhancing its in vitro toxicity. Apart from this metabolic interaction, no mixtures showed any interaction, and all binary mixtures were successfully modeled by at least one model based on exposure to the individual compounds.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology and Applied Pharmacology - Volume 305, 15 August 2016, Pages 118-126
Journal: Toxicology and Applied Pharmacology - Volume 305, 15 August 2016, Pages 118-126
نویسندگان
S. Teng, C. Tebby, S. Barcellini-Couget, G. De Sousa, C. Brochot, R. Rahmani, A.R.R. Pery,