کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5847985 | 1561621 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A novel toxicity mechanism of CdSe nanoparticles to Saccharomyces cerevisiae: Enhancement of vacuolar membrane permeabilization (VMP)
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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چکیده انگلیسی
Cadmium selenide (CdSe) nanoparticles are implemented in a wide range of applications, but their potential risk to the ecosystem, especially to the organisms essential for the maintenance of ecosystem homeostasis, such as fungal populations, plants and bacteria, remains to be elucidated. In this study, we investigated their toxicity to one of the most important fungal model organisms, Saccharomyces cerevisiae. Growth inhibition assays revealed that the synthesized CdSe nanoparticles with the sizes of 20-30Â nm had strong inhibitory effect on yeast growth (IC50Â =Â 80Â ppm). This toxicity was not attributed to mitochondrial dysfunction and autophagy, but was dependent on End3-mediated endocytosis, and was associated with reactive oxygen species (ROS) accumulation and an enhancement of vacuolar membrane permeabilization (VMP). These results reveal a key role of the vacuole during the interaction between CdSe nanoparticles and yeast cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 220, 5 September 2014, Pages 208-213
Journal: Chemico-Biological Interactions - Volume 220, 5 September 2014, Pages 208-213
نویسندگان
Meiqing Sun, Qilin Yu, Ming Liu, Xiaoyan Chen, Zhe Liu, Hao Zhou, Yingjin Yuan, Lu Liu, Mingchun Li, Chengdong Zhang,