کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5847988 1561621 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The depletion of securin enhances butein-induced apoptosis and tumor inhibition in human colorectal cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
The depletion of securin enhances butein-induced apoptosis and tumor inhibition in human colorectal cancer
چکیده انگلیسی


- Butein down-regulates securin for apoptosis induction.
- Depletion of securin mediates butein-inhibited colorectal tumor.
- Butein potentially provides colorectal cancer therapy.

Butein (3,4,2′,4′-tetrahydroxychalcone) is a promising natural polyphenolic compound that shows the growth inhibitory activity in human cancer cells; however, the precise mechanism is still unclear. Securin plays pivotal role in cancer cell proliferation and tumorigenesis. Here, we report the presence of securin that could modulate apoptosis and tumor growth ability in the butein-treated human colorectal cancer. Butein induced caspase-3 activation and PARP protein cleavage for apoptosis induction in human colorectal cancer cells. Interestingly, butein reduced the securin protein levels but conversely increased the phospho-histone H3 proteins, mitotic arrest and abnormal chromosomes segregation in cancer cells. The securin-null colorectal cancer cells were more sensitive on the reduction of cell viability than the securin-wild type cancer cells following butein treatment. The loss of securin in human colorectal cancer cells decreased tumor growth ability in nude mice. Moreover, butein reduced the tumor size of xenografted human colorectal tumors of nude mice. Taken together, this study demonstrates for the first time that the depletion of securin mediates the butein-induced apoptosis and colorectal tumor inhibition.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 220, 5 September 2014, Pages 41-50
نویسندگان
, , , , , ,