Assessing protection against OP pesticides and nerve agents provided by wild-type HuPON1 purified from Trichoplusia ni larvae or induced via adenoviral infection

► HuPON1 from insect cells protects guinea pigs from OP pesticide toxicity. ► HuPON1 from insect cells does not protect guinea pigs from OP nerve agents. ► Adenovirus-induced HuPON1 does not protect mice from OP nerve agents.