Strategies for the selection of catalytic antibodies against organophosphorus nerve agents

► Organophosphorus nerve agents neutralization is an important task. ► Antibodies with catalytic activity (abzymes) may be effectively used for this purpose. ► Transition state analogs approach is widely used for abzyme generation. ► Anti-idiotypic antibodies are internal image of phosphorous-metabolizing enzymes. ► Reactibodies are novel class of abzymes with pre-determinate mechanism of catalysis.